Cholesterol Level Regulates Endosome Motility via Rab Proteins
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چکیده
منابع مشابه
The VPS-34 PI3 kinase negatively regulates RAB-5 during endosome maturation
The Rab5 GTPase and phosphatidylinositol-3 phosphate (PI(3)P) coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III PI3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P binding proteins. Loss of Rab5 and loss of Vps34 have opposite effects on endosome size suggesting that our understanding of how Rab5 and PI(3)P cooperate is incomplete. Here we report a novel regula...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.099366